Fertility of Transgenic Female Mice Expressing Bovine Growth Hormone or Human Growth Hormone Variant Genes1
نویسندگان
چکیده
منابع مشابه
Transgenic mice containing growth hormone fusion genes.
New genes composed of the mouse metallothionein I promoter-regulator and the rat or human growth hormone structural gene have been introduced into mice. A large proportion of mice containing these genes express them, and some animals grow to be up to twice as large as controls. The technique has been used in part to correct the genetic defect that results in the small stature of the mutant litt...
متن کاملEndothelial dysfunction in growth hormone transgenic mice.
Acromegaly [overproduction of GH (growth hormone)] is associated with cardiovascular disease. Transgenic mice overexpressing bGH (bovine GH) develop hypertension and hypercholesterolaemia and could be a model for cardiovascular disease in acromegaly. The aims of the present study were to investigate the effects of excess GH on vascular function and to test whether oxidative stress affects endot...
متن کاملHuman growth hormone increases apo(a) expression in transgenic mice.
Levels of Lp(a), an atherogenic lipoprotein that circulates in human plasma, are increased by the administration of growth hormone (GH). Many of the physiological effects of GH are mediated through insulin-like growth factor-1 (IGF-1), but ironically, IGF-1 treatment of humans is associated with a fall in plasma Lp(a) levels. To glean insight into the mechanism responsible for the GH-associated...
متن کاملLipid composition of carcass tissue from transgenic pigs expressing a bovine growth hormone gene.
Fatty acid profiles and cholesterol content of whole-carcass ground tissue were compared from 26 transgenic (T) pigs expressing a bovine growth hormone gene (bGH) to 26 sibling control (C) pigs. All pigs were fed a common diet and were slaughtered at five different live weights: 14, 28, 48, 68, and 92 kg. The left side of each intact carcass was ground and tissue samples were analyzed for lipid...
متن کاملتأثیر پلی مورفیسم های ژن های هورمون رشد growth hormone و گیرنده ژن هورمون رشد growth hormone receptor روی برخی صفات اقتصادی بز مرغز ایران
در این پژوهش به بررسی وجود پلی مورفیسم در ناحیه پروموتور و اگزون 10 ژن های gh و ghr و ارتباط آنها با صفات رشد در بزهای مرغز پرداخته شد. بدین منظور از سیاهرگ وداج تعداد 160 بز مرغز موجود در ایستگاه اصلاح نژاد استان کردستان خونگیری و dna نمونه ها با استفاده از کیت استخراج گردید. قطعه 391 جفت بازی از ژن gh و 361 جفت بازی از ژن ghr تکثیر شدند. از تفاوت چندشکلی فضایی تک رشته ها (sscp) و توالی یابی ب...
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ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 1991
ISSN: 0006-3363,1529-7268
DOI: 10.1095/biolreprod45.1.178